Rab7Protein Q67L mutant-蛋白质/抗原/多肽-试剂-生物在线
武汉纽斯特生物技术有限公司
Rab7Protein Q67L mutant

Rab7Protein Q67L mutant

商家询价

产品名称： Rab7Protein Q67L mutant

英文名称： Rab7Protein Q67L mutant

产品编号： 10135

产品价格： 0

产品产地： 美国

品牌商标： NewEastBio

更新时间： null

使用范围： null

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Rab7 Protein Q67L mutant [10135]
[25 µg]		  
Catalog Number:  10135
Product Name:  Rab7 Protein Q67L mutant
Synonyms:  Member RAS oncogene family, Rab7a, MGC102153
Source:   Human, recombinant full length, His6-tag
Expression Host:   E. coli
Molecular Weight:   23 kDa
Purity:   >95% by SDS-PAGE
Introduction:   Members of the Rab family of Ras-related GTP-binding proteins are important regulators of vesicular transport and are located in specific intracellular compartments. Rab7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori.
Amino Acid Sequence   (1-207, Q67L)
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGL 
ERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQV 
ATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEVELYNEFPEPIKLDKNDRAKASAES 
CSC
Properties
Physical Appearance (form):   Dissolved in 20mM Tris-HCl, pH8.0, 150mM NaCl.
Physical Appearance (form):  White or clear
Concentration:  1 mg/mL
Storage:   -80°C
Preparation Instructions:  
Centrifuge the vial before open the cap and reconstitute in water. Adding of 10 mM β-mercaptoethanol or 1 mM DTT into the solution to protect the protein is recommended and using of non-ionic detergents such as n-Dodecyl β-D-maltoside (DoDM) or polyethylene detergents (e.g. C12E10) also help to stabilize the protein. Avoid repeated freezing and thawing after reconstitution. The purity of His-tagged Rab7 Q67L was determined by SDS-PAGE and Coomassie Brilliant Blue Staining.
References:  
1. Edinger, A. L. et al., Dev. Cell 5: 571-582, 2003. 2. Houlden, H. et al., Ann. Neurol. 56: 586-590, 2004. 
3. Meggouh, F. et al., Neurology 67: 1476-1478, 2006. 
4. Rak, A. et al., Cell 117: 749-760, 2004. 
5. Verhoeven, K. et al., Am. J. Hum. Genet. 72: 722-727, 2003.