产品索引
        

        
产品数据 
        

          

            

              

                货号
              
              
LPA33383
              

                文献
              
              

                详细请查看官网 
              
            

            

              

                产品名称
              
              
MUC5AC (ABT-MUC5AC) mouse Monoclonal Antibody
            
            

              

                中文名称
              
              
MUC5AC (ABT-MUC5AC) 小鼠单克隆抗体
            
            

              
规格
              
100ug
              
适应种属
              
Human
            
            

              

                纯化方法
              
              
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
              

                UniProt ID
              
              

                
              
            
            

              

                浓度
              
              
1mg/ml
              

                宿主
              
              
Mouse/IgG1
            
            

              

                克隆性
              
              
Monoclonal
              

                亚型
              
              
IgG1
            
            

              

                免疫原
              
              
Synthesized peptide derived from human MUC5AC 
              

                分子量
              
              

            
            

              

                验证应用
              
              
IHC-p
            
            

              

                验证应用
              
              
Liquid
            
            

              

                建议稀释比例
              
              
IHC-p 1:100-500
              

                存储条件
              
              
-20°C/1 year
            
            

              

                偶联物
              
              
Unconjugated 
              

                储存溶液
              
              
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. 
            
            

              

                运输条件
              
              

                所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。
              
            
            

              

                注意事项
              
              

                该产品仅供科研使用
              
            
          
        
        

        
背景介绍
        
domain:The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.,function:Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system.,PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.,PTM:Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 2 VWFC domains.,similarity:Contains 4 VWFD domains.,subunit:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).,tissue specificity:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.,

        
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