D-Dimer 小鼠单克隆抗体
产品名称： D-Dimer 小鼠单克隆抗体
英文名称： D-Dimer Mouse monoclonal antibody
产品编号： LPMA10270
产品价格： null
产品产地： 中国
品牌商标： Ablepscience
更新时间： null
使用范围：
- 联系人 :
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- 邮编 : 430075
- 所在区域 : 湖北
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- 邮箱 : sale@apescience.cn;3055949650@qq.com
产品索引
Fibrinogen alpha chain;Fibrinogen beta chain;Fibrinogen gamma chain
产品数据
货号 LPMA10270 文献 详细请查看官网 产品名称 Anti D-Dimer mouse monoclonal antibody 中文名称 D-Dimer 小鼠单克隆抗体 规格 100ug 适应种属 Human 纯化方法 Protein G purified from mice ascites UniProt ID P02671;P02675;P02679 浓度 1mg/ml 宿主 Mouse 克隆? Monoclonal 亚型 IgG 1 免疫原 D-Dimer purified from human 分子量 95 kDa 验证应用 Elisa,WB,IHC 验证应用 Liquid 建议稀释比例 Elisa:1:1000~5000;WB:1:1000~4000,IHC:1:50~100 存储条件 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 °C for frequent use. Store at -20 to -80 °C for twelve months from the date of receipt. 偶联物 Unconjugate 储存溶液 PBS, pH7.4, containing 0.05% proclin300, 50% glycerol. 运输条件 所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。 注意事项 该产品仅供科研使用
背景介绍
The liver produces several important proteins involved in the coagulation process, one of which includes fibrinogen. A single fibrinogen molecule is a symmetrical dimer that is made up of three pairs of three different polypeptide chains, which include a, b and g.Each of the intertwined polypeptide chains that comprise a single fibrinogen molecule is held together by disulfide bonds.The formation of fibrin begins with the cleaving of the a and b polypeptide chains of the fibrinogen molecule, which is achieved by thrombin. This cleaving event causes the fibrin monomers to spontaneously polymerize, which results in the formation of double-stranded fibrin protofibrils.To strengthen a normally weak network that exists between the fibrin monomers and the protofibrils, a transglutaminase enzyme known as factor XIIa is activated.If an injury occurs, the fibrinolytic system will activate to limit the size of the clot. This system begins with the release of the plasminogen activator from the vascular endothelial cells to allow this molecule to bind to the fibrin surface of plasmin.Fibrin-bound plasmin will then degrade the fibrin network into several soluble fragments, of which will include the D-dimer of the (DD)E complex.