产品索引
        

        
产品数据 
        

          

            

              

                货号
              
              
LPA31217
              

                文献
              
              

                详细请查看官网 
              
            

            

              

                产品名称
              
              
IDE mouse Monoclonal Antibody(3H4)
            
            

              

                中文名称
              
              
IDE 小鼠单克隆抗体(3H4)
            
            

              
规格
              
100ug
              
适应种属
              
Human
            
            

              

                纯化方法
              
              
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
              

                UniProt ID
              
              

                
              
            
            

              

                浓度
              
              
1mg/ml
              

                宿主
              
              
Mouse
            
            

              

                克隆性
              
              
Monoclonal
              

                亚型
              
              

            
            

              

                免疫原
              
              
Synthetic Peptide of IDE 
              

                分子量
              
              

            
            

              

                验证应用
              
              
WB,IHC-p,IF,
            
            

              

                验证应用
              
              
Liquid
            
            

              

                建议稀释比例
              
              
WB: 1:1000 IF 1:200 IHC 1:50-300
              

                存储条件
              
              
-20°C/1 year
            
            

              

                偶联物
              
              
Unconjugated 
              

                储存溶液
              
              
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol. 
            
            

              

                运输条件
              
              

                所有可选规格：常温运输或根据产品储存温度要求用蓝冰运输。
              
            
            

              

                注意事项
              
              

                该产品仅供科研使用
              
            
          
        
        

        
背景介绍
        
insulin degrading enzyme(IDE)   Homo sapiens    This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe

        
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