GCNF,维甲酸受体相关睾丸受体抗体

产品编号HZ-11558R
英文名称GCNF
中文名称生殖细胞核因子GCNF/维甲酸受体相关睾丸受体抗体
别 名GCNF 1; GCNF; GCNF1; Germ cell nuclear factor; hGCNF; hRTR; NR 61; NR61; NR6A1; NR6A1_HUMAN; Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor NR6A1; Retinoic acid receptor related testis associated receptor; Retinoid receptor related testis specific receptor; Retinoid receptor-related testis-specific receptor; RTR.
说 明 书0.1ml 0.2ml
研究领域细胞生物 发育生物学 神经生物学 信号转导 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
GCNF,维甲酸受体相关睾丸受体抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human GCNF (251-350aa)
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
GCNF,维甲酸受体相关睾丸受体抗体PubMedPubMed
产品介绍background:
Germ cell nuclear factor (GCNF) is an orphan member of the nuclear receptor gene superfamily that influences neurogenesis and germ cell development. GCNF can homodimerize and bind DNA. GCNF regulates paracrine interaction between the oocyte and somatic cells by regulating the expression of BMP-15 and GDF-9, to affect female fertility. GCNF is present in spermatocytes and round spermatids of adult male mouse testis; northern blot and ribonuclease protection assays have shown GCNF is predominant in the testis. The gene expresses three alternatively spliced transcript variants.

Function:
Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.

Subunit:
Homodimer. Interacts with UIMC1

Subcellular Location:
Nucleus.

Tissue Specificity:
Shows highest expression in the germ cells of the adult testis.

Similarity:
Belongs to the nuclear hormone receptor family. NR6 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

GCNF,维甲酸受体相关睾丸受体抗体Database links:
UniProtKB/Swiss-Prot: Q15406.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.