CASP3 monoclonal antibody, clone CPP32 4-1-18
产品名称： CASP3 monoclonal antibody, clone CPP32 4-1-18
英文名称： CASP3 monoclonal antibody, clone CPP32 4-1-18
产品编号： MAB2360
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant CASP3.
- Immunogen:
- Recombinant protein corresponding to full length human CASP3.
- Host:
- Mouse
- Reactivity:
- Human, Rat
- Form:
- Liquid
- Isotype:
- IgG2a, kappa
- Storage Buffer:
- In buffer containing 0.1% sodium azide
- Storage Instruction:
- Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
- Recommend Usage:
- Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.
Nikiforov MA, Riblett M, Tang WH, Gratchouck V, Zhuang D, Fernandez Y, Verhaegen M, Varambally S, Chinnaiyan AM, Jakubowiak AJ, Soengas MS.Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19488-93. Epub 2007 Nov 27.
- 2.
- Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c.
Kirsch DG, Doseff A, Chau BN, Lim DS, de Souza-Pinto NC, Hansford R, Kastan MB, Lazebnik YA, Hardwick JM.J Biol Chem. 1999 Jul 23;274(30):21155-61.
- 3.
- Oncogene-dependent apoptosis is mediated by caspase-9.
Fearnhead HO, Rodriguez J, Govek EE, Guo W, Kobayashi R, Hannon G, Lazebnik YA.Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13664-9.
- Entrez GeneID:
- 836
- Protein Accession#:
- P42574
- Gene Name:
- CASP3
- Gene Alias:
- CPP32,CPP32B,SCA-1
- Gene Description:
- caspase 3, apoptosis-related cysteine peptidase
- Omim ID:
- 600636
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
- Other Designations:
- OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related cysteine protease,cysteine protease CPP32,procaspase3
- Interactome
- Related Disease
- Adenocarcinoma
- Attention Deficit Disorder with Hyperactivity
- Autistic Disorder
- Carcinoma, Large Cell
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Clubfoot
- Colorectal Neoplasms
- Diabetes Mellitus, Type 2
- Diabetic Nephropathies
- Disease Progression
- Edema
- Endometrial Neoplasms
- Esophageal Neoplasms
- Gastrointestinal Stromal Tumors
- Genetic Predisposition to Disease
- Head and Neck Neoplasms