Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
产品名称： Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
英文名称： Iterative Crystallography Service：Neurotrophic Factor Artemin Isoform 3
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http://www.creative-biostructure.com/Iterative-crystallography/Iterative-crystallography-CBCRY32.htm
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Cat. No. |
CBCRY32 |
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Background |
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET. |
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Molecular description |
Protein Classification |
Hormone/growth Factor |
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Structure Weight |
11574.40 Da |
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Polymer |
1 |
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Molecule |
neurotrophic factor artemin isoform 3 |
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Chain Length |
105 amino acids |
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Crystal Description |
PDB ID |
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MMDB ID |
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Source |
E.coli |
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Method |
X-Ray Diffraction |
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Resolution |
1.76Å |
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Gene information |
Gene Name |
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Synonyms |
ENOVIN; EVN; NBN; OTTHUMP00000009173; OTTHUMP00000009174; neublastin; neurotrophic factor; neurotrophic factor artemin |
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UniProt ID |
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GeneID |
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Chromosome Location |
1p33-p32 |
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Function |
growth factor activity; receptor binding |
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Reference |
Wang, X., Baloh, R.H., Milbrandt, J., Garcia, K.C. (2006) Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure 14: 1083-1092 |
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