人参皂苷Ro
产品名称： 人参皂苷Ro
英文名称： Ginsenoside Ro
产品编号： 34367-04-9
产品价格： 0
产品产地： 吉林长春
品牌商标： 星海金森
更新时间： null
使用范围： null
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- 地址 : 常熟高新技术产业开发区湖山路333号同济科技广场
- 邮编 :
- 所在区域 : 江苏
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- 邮箱 : sales@star-ocean-biotech.com;star-ocean@vip.163.com
Ginsenoside Ro Biological Activity
IC50 Value & Target: 259.4 μm (for 5α-reductase )
In Vitro: Ginsenoside Ro exhibited suppressive activities on reactive oxygen species and matrix metalloproteinase-2 elevation in UV-B-irradiated fibroblasts. Ginsenoside Ro could overcome the reduction of the total glutathione contents in UV-B-irradiated fibroblasts. In IL-1β-induced rat chondrocytes, ginsenoside Ro exerted anti-apoptosis and anti-inflammation. Ro could improve IL-1β-induced chondrocytes viability. Ginsenoside Ro could suppress IL-1β-induced apoptosis by inhibiting levels of Bax and Bad, decreasing p53 phosphorylation and promoting the expression of Bcl-xL and PCNA. Ginsenoside Ro inhibited caspase 3 activity. IL-1β-induced inflammation and matrix degration were also alleviated by Ginsenoside Ro with down-regulating the expression of MMP 3, MMP 9 and COX-2. Moreover, ginsenoside Ro inhibited NF-κB p65 phosphorylation induced by IL-1β [2].
In Vivo: Topical administration of ginsenoside Ro (0.2 mg/mouse) to shaved skin inhibited hair re-growth suppression after shaving in the testosterone-treated C57BL/6 mice. Ginsenoside Ro showed inhibitory activity against 5αR with IC(50) value of 259.4 μm [3].
  | Dave Gao Sales Manager, Star Ocean Ginseng Professional Services Tel: +86 512 81662860 Mobile: +86 13776237441 Fax: +86 512 52856900 Address: High Tech Industrial Development Zone-Tongji Science and Technology Plaza, Changshu, Suzhou, China. |