TMPRSS5,跨膜丝氨酸蛋白酶5抗体

产品编号HZ-11183R
英文名称TMPRSS5
中文名称跨膜丝氨酸蛋白酶5抗体
别 名Spinesin; TMPRSS 5; TMPRSS-5; TMPRSS5; TMPS5_HUMAN; Transmembrane protease serine 5; Transmembrane protease, serine 5 (spinesin); Transmembrane protease, serine 5; MGC141886; MGC148044; OTTHUMP00000238209; OTTHUMP00000238210; OTTHUMP00000238211; OTTHUMP00000238212; OTTHUMP00000238213.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 神经生物学 跨膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
TMPRSS5,跨膜丝氨酸蛋白酶5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量50kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TMPRSS5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
TMPRSS5,跨膜丝氨酸蛋白酶5抗体PubMedPubMed
产品介绍background:
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. TMPRSS5 (transmembrane protease, serine 5), also known as spinesin, is a 457 amino acid single-pass type II membrane protein that is expressed specifically in brain and is thought to play a role in hearing. A member of the peptidase S1 family, TMPRSS5 contains one peptidase S1 domain and an SRCR domain, and is encoded by a gene that maps to human chromosome 11q23.2. Defects in the gene encoding TMPRSS5 are associated with deafness.

Function:
May play a role in hearing.

Subcellular Location:
Cell membrane.

Post-translational modifications:
Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord.

DISEASE:
Note=Defects in TMPRSS5 may be a cause of deafness.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.

Gene ID:
80975

Database links:
Entrez Gene: 80975 Human
Entrez Gene: 80893 Mouse
Entrez Gene: 266681 Rat
Omim: 606751 Human
SwissProt: Q9H3S3 Human
SwissProt: Q9ER04 Mouse
Unigene: 46720 Human
Unigene: 72799 Mouse

TMPRSS5,跨膜丝氨酸蛋白酶5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.