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Anti-PPP1A成都正能生物技术有限责任公司

性能参数

产品名称: Anti-PPP1A
抗体货号: 200225
产品规格: 100ul
级    别: Affinity purified
产品产地: 成都正能生物
品牌商标: Zen BioScience
价    格: 3680元
抗原来源: Human
抗体来源: Mouse
适用物种: H
Isotype:IgG1
应用范围: WB,IHC,ICC
更新时间: 2019/6/30 13:21:00
详细资料:  实验方法技术资料
浏览人数:697
诚信指数:121点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

成都正能生物技术有限责任公司
地址:
中国成都高新区科园南路爱斯特大厦
邮编:
610200
电话:
028-85739596
传真:
+86-028-85739596
联系人:
小能
所在区域:
四川·成都
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产品详细描述

Size  100ug

Cat code  200225

Species Cross-reactivity  H

Key Application  WB,IHC,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG1

Molecular Weight  38kDa

Sensitivity  This antibody detects endogenous levels of PPP1CA and does not cross-react with related proteins.

Immunogen  Purified recombinant human PPP1CA protein fragments expressed in E.coli.

UniProt Number  P62136

GeneBank ID  NM_001008709

Subcellular location  Cytoplasm. Nucleus. Nucleus

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol

Altername  serine/threonine-protein phosphatase PP1-alpha catalytic subunit;protein phosphatase 1; catalytic subunit, alpha isoform;serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit;Protein Phosphatase 1 alpha;PPP1CA

Gene_symbol  PP-1A; PPP1A; PP1alpha

Summary  The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniPort summary Function  Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage.

Application Images :  

Western blot detection of PPP1CA in MCF7 , K562 ,Hela ,HEPG2 &Jurkat Whole cell lysates using PPP1CA antibody (1:1000 diluted). Predicted band size: 38KDa Observed band size: 38KDa

Immunocytochemistry stain of Hela using PPP1CA antibody (1:300).

IHC of paraffin-embedded human breast cancer using anti- PPP1CA diluted 1/500-1/1000.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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