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Anti-TIF1 gamma / TRIM33成都正能生物技术有限责任公司

性能参数

产品名称: Anti-TIF1 gamma / TRIM33
抗体货号: 200309
产品规格: 100ul
级    别: Affinity purified
产品产地: 成都正能生物
品牌商标: Zen BioScience
价    格: 2780元
抗原来源: Human
抗体来源: Mouse
适用物种: H
Isotype:IgG2a
应用范围: WB,ICC
更新时间: 2019/7/4 12:21:00
详细资料:  实验方法技术资料
浏览人数:553
诚信指数:121点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

成都正能生物技术有限责任公司
地址:
中国成都高新区科园南路爱斯特大厦
邮编:
610200
电话:
028-85739596
传真:
+86-028-85739596
联系人:
小能
所在区域:
四川·成都
邮件:
公司展台:
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产品详细描述

Size  100ug

Cat code  200309

Species Cross-reactivity  H

Key Application  WB,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG2a

Molecular Weight  140kDa

Sensitivity  This antibody detects endogenous levels TRIM33 and does not cross-react with related proteins.

Immunogen  Purified recombinant human TRIM33 protein fragments expressed in E.coli.

UniProt Number  Q9UPN9

GeneBank ID  NM_015906

Subcellular location  Nucleus

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Altername  ECTO; PTC7; RFG7; TF1G; TIF1G; FLJ32925; TIFGAMMA; TIF1GAMMA

Gene_symbol  ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA

Summary  The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

UniPort summary Function  Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Application Images :  

Western blot detection of TRIM33(C-terminus) antibody in MCF7&HelaNE cell lysates using TRIM33(C-terminus) antibody (1:1000 diluted). Predicted band size: 120KDa Observed band size: 140KDa

Immunocytochemistry of HeLa cells using anti-TRIM33 (C-terminus) antibody diluted 1:50.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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