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Anti-Aurora Kinase A成都正能生物技术有限责任公司

性能参数

产品名称: Anti-Aurora Kinase A
抗体货号: 200525
产品规格: 100ul
产品产地: 成都正能生物
品牌商标: Zen BioScience
价    格: 1880元
抗原来源: Human
抗体来源: Mouse
适用物种: H,Mk
Isotype:IgG1
应用范围: WB
更新时间: 2019/6/29 14:20:00
详细资料:  实验方法技术资料
浏览人数:632
诚信指数:121点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

成都正能生物技术有限责任公司
地址:
中国成都高新区科园南路爱斯特大厦
邮编:
610200
电话:
028-85739596
传真:
+86-028-85739596
联系人:
小能
所在区域:
四川·成都
邮件:
公司展台:
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产品详细描述

Size  100ug

Cat code  200525

Species Cross-reactivity  H,Mk

Key Application  WB

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  null

Isotype  IgG1

Molecular Weight  46kDa

Sensitivity  This antibody detects endogenous levels of AURKA(N-term) and does not cross-react with related proteins.

Immunogen  Purified recombinant human AURKA(N-term) protein fragments expressed in E.coli.

UniProt Number  O14965

GeneBank ID  NM_198437

Subcellular location  Cytoplasm

Formulation  ascites

Altername  aurora 2,IPL1-related kinase,aurora-related kinase 1,aurora/IPL1-like kinase,serine/threonine kinase 6,aurora/IPL1-related kinase 1 breast tumor-amplified kinase,breast-tumor-amplified kinase serine/threonine-protein kinase 6 serine/threonine protein kinase 15 serine/threonine-protein kinase 15 serine/threonine-protein kinase aurora-A protein phosphatase 1, regulatory subunit 47

Gene_symbol  AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; AURORA2; PPP1R47

Summary  The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

UniPort summary Function  Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizating p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.

Application Images :  

Western blot detection of AURKA in HL60, SW480, MCF7, 293, COS7 & HepG2 cell lysates and using AURKA antibody (1:200 diluted). Predicted band size: 46KDa Observed band size:46KDa

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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