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Anti-NPM1成都正能生物技术有限责任公司

性能参数

产品名称: Anti-NPM1
抗体货号: 200143
产品规格: 100ul
级    别: Affinity purified
产品产地: 成都正能生物
品牌商标: Zen BioScience
价    格: 2380元
抗原来源: Human
抗体来源: Mouse
适用物种: H,M
Isotype:IgG1
应用范围: WB,ICC
更新时间: 2019/7/14 12:22:00
详细资料:  实验方法技术资料
浏览人数:594
诚信指数:121点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

供应商联系卡

成都正能生物技术有限责任公司
地址:
中国成都高新区科园南路爱斯特大厦
邮编:
610200
电话:
028-85739596
传真:
+86-028-85739596
联系人:
小能
所在区域:
四川·成都
邮件:
公司展台:
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产品详细描述

Size  100ug

Cat code  200143

Species Cross-reactivity  H,M

Key Application  WB,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG1

Molecular Weight  38kDa

Sensitivity  This antibody detects endogenous levels of NPM1 and does not cross-react with related proteins.

Immunogen  Purified recombinant full length of human NPM1 protein expressed in E.coli.

UniProt Number  P06748

GeneBank ID  NM_002520

Subcellular location  Nucleus, Cytoplasm

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Altername  B23; NPM; MGC104254

Gene_symbol  B23; NPM

Summary  This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.

UniPort summary Function  Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules.

Application Images :  

Western blot detection of NPM1 antibody in Hela,Jurkat&3T3 cell lysates using NPM1 antibody (1:1000 diluted). Predicted band size:33KDa. Observed band size:38KDa.

Immunocytochemistry of HeLa cells using anti- NPM1 antibody diluted 1:200

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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