Cat code 200266
Species Cross-reactivity M
Key Application WB
Antibody type Monoclonal antibody
Purified method Affinity purified
Molecular Weight 54kDa
Sensitivity This antibody detects endogenous levels PPAR gamma and does not cross-react with related proteins.
Immunogen Purified recombinant human PPAR gamma protein fragments expressed in E.coli.
UniProt Number P37231
GeneBank ID NM_138711
Subcellular location Nucleus
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Altername GLM1; CIMT1; NR1C3; PPARG1; PPARG2;
Gene_symbol GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
Summary This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
UniPort summary Function Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis
Application Images :
Western blot detection of PPAR gamma antibody in 3T3-L1&Mouse Lung cell lysates using PPAR gamma antibody (1:1000 diluted). Predicted band size:54KDa. Observed band size:54KD
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