Anti-PP1C-抗体-抗体-生物在线
Anti-PP1C

Anti-PP1C

商家询价

产品名称: Anti-PP1C

英文名称: Anti-PP1C

产品编号: 200452

产品价格: null

产品产地: 成都正能生物

品牌商标: Zen BioScience

更新时间: null

使用范围: WB

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Size  100ug

Cat code  200452

Species Cross-reactivity  H

Key Application  WB

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  Affinity purified

Isotype  IgG2b

Molecular Weight  38kDa

Sensitivity  This antibody detects endogenous levels of PPP1CC and does not cross-react with related proteins.

Immunogen  Purified recombinant human PPP1CC protein fragments expressed in E.coli.

UniProt Number  P36873

GeneBank ID  NM_002710

Subcellular location  Cytoplasm.Nucleus.Nucleus ? nucleolus.Nucleus ? nucleoplasm.Nucleus speckle.Chromosome ? centromere ? kinetochore.Cleavage furrow.Midbody.Mitochondrion.

Formulation  Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.

Altername  EC 3.1.3.16;PP 1G;PP-1G;PP1G;PP1G_HUMAN;PP1gamma;PPP 1G;PPP1CC;PPP1CC protein;PPP1G;Protein phosphatase 1 catalytic subunit gamma isoform;Protein phosphatase 1C catalytic subunit;Protein phosphatase 1C subunit;Protein phosphatase 2C gamma isoform;Serine/threonine phosphatase 1 gamma;Serine/threonine protein phosphatase PP1 gamma catalytic subunit;Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.

Gene_symbol  PP1C;PP-1G;PPP1G.

Summary  The protein encoded by this gene belongs to the protein phosphatase family,PP1 subfamily.PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes,including cell division.It is expressed in mammalian cells as three closely related isoforms,alpha,beta/delta and gamma,which have distinct localization patterns.This gene encodes the gamma isozyme.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq,Oct 2011]

UniPort summary Function  Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.Protein phosphatase 1(PP1)is essential for cell division,and participates in the regulation of glycogen metabolism,muscle contractility and protein synthesis.Dephosphorylates RPS6KB1.Involved in regulation of ionic conductances and long-term synaptic plasticity.May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.Component of the PTW/PP1 phosphatase complex,which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

Application Images :  

Western blot detection of PPP1CC antibody in Hela,293T and Jurkat cell lysates using PPP1CC antibody (1:500 diluted).Predicted band size:38KDa.Observed band size:38KDa.