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Anti-Noggin

Anti-Noggin

商家询价

产品名称: Anti-Noggin

英文名称:

产品编号: 200888

产品价格: null

产品产地: 成都正能生物

品牌商标: Zen BioScience

更新时间: null

使用范围: WB,ICC

成都正能生物技术有限责任公司
  • 联系人 :
  • 地址 : 中国成都高新区科园南路爱斯特大厦
  • 邮编 : 610200
  • 所在区域 : 四川
  • 电话 : 180****2350
  • 传真 : +86-028-85739596
  • 邮箱 : sales@zen-bioscience.com

Size  100ug

Cat code  200888

Species Cross-reactivity  

Key Application  WB,ICC

Host  Mouse

Antibody type  Monoclonal antibody

Purified method  

Isotype  IgG3

Molecular Weight  26kDa

Sensitivity  This antibody detects endogenous levels of NOG and does not cross-react with related proteins.

Immunogen  Purified recombinant human NOG protein fragments expressed in E.coli.

UniProt Number  Q13253

GeneBank ID  NM_005450

Subcellular location  Secreted.

Formulation  ascites

Altername  NOG;NOGG_HUMAN;Noggin;SYM 1;SYM1;Symphalangism 1 (proximal);Synostoses (multiple) syndrome 1;SYNS 1;SYNS1.

Gene_symbol  SYM1;SYNS1.

Summary  The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins,such as bone morphogenetic protein-4 (BMP4).By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily,this protein may have a principal role in creating morphogenic gradients.The protein appears to have pleiotropic effect,both early in development as well as in later stages.It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment.The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes,such as neural tube fusion and joint formation. Recently,several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified;both SYM1 and SYNS1 have multiple joint fusion as their principal feature,and map to the same region (17q22) as this gene.All of these mutations altered evolutionarily conserved amino acid residues.The amino acid sequence of this human gene is highly homologous to that of Xenopus,rat and mouse.[provided by RefSeq,Jul 2008]

UniPort summary Function  Essential for cartilage morphogenesis and joint formation.Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.

Application Images :  

Western blot detection of NOG antibody in CHO-K1 cell lysates over-expressing NOG-PDGFR transmembrane domain fused protein using NOG antibody (1:1000 diluted).Predicted band size:26KDa.Observed band size:37KDa.

Immunocytochemistry staining of HeLa cells surface-expressing NOG-PDGFR transmembrane domain fused protein using anti-NOG antibody (dilution 1:100).