Anti-Amyloid Oligomers (A11) pAb
产品名称: Anti-Amyloid Oligomers (A11) pAb
英文名称: Amyloid Oligomers (A11) Polyclonal Antibody
产品编号: SPC-506D
产品价格: null
产品产地: 加拿大
品牌商标: StressMarq
更新时间: null
使用范围: ELISA, IF, IHC, IP, WB
- 联系人 :
- 地址 : 加拿大
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- 所在区域 : 其他
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- 传真 : 123456
- 邮箱 : hedyl@stressmarq.com
Dot blot analysis of Aβ42 and polyQ36 prefibrillar oligomers and fibrils. Aβ42 and polyQ fibrils only stain with OC serum (Catalog # SPC-507), while Aβ42 and polyQ prefibrillar oligomers only react with A11 (Catalog # SPC-506). Picture courtesy of Kayed et al., (2007) Biomed Central: Molecular Neurodegeneration, 2: 18.
Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils.
Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres. These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson’s disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease.