AF 4,原癌基因AF4蛋白抗体

产品编号HZ-5958R
英文名称AF 4
中文名称原癌基因AF4蛋白抗体
别 名AF 4; AF 4 protein; AF-4 protein; AF4/FMR2 family member 1; AFF 1; AFF1; AFF1_HUMAN; ALL1 fused gene from chromosome 4; ALL1-fused gene from chromosome 4 protein; FEL; MLLT2; MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA TRANSLOCATED TO 2; MLLT2; Protein AF-4; Protein FEL; Proto-oncogene AF4; AF4; PBM1. .
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 染色质和核信号 信号转导
抗体来源Rabbit
AF 4,原癌基因AF4蛋白抗体克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Rabbit,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量133kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human AF 4 protein
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AF 4,原癌基因AF4蛋白抗体PubMedPubMed
产品介绍background:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.

Subcellular Location:
Nucleus.

DISEASE:
Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with MLL/HRX. The result is a rogue activator protein.

Similarity:
Belongs to the AF4 family.

Gene ID:
4299

Database links:
Entrez Gene: 17355 Mouse
Omim: 159557 Mouse
SwissProt: O88573 Mouse
Unigene: 6949 Mouse

AF 4,原癌基因AF4蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.