CD6,CD6抗体

产品编号HZ-2488R
英文名称CD6
中文名称CD6抗体
别 名CD_antigen=CD6; CD6; CD6 antigen Tp120; CD6_HUMAN; FLJ44171; OX52; T cell differentiation antigen CD6; T-cell differentiation antigen CD6; T12; TP120.
说 明 书0.1ml 0.2ml
研究领域细胞生物 干细胞 淋巴细胞 t-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
CD6,CD6抗体分 子 量70kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD6,CD6抗体PubMedPubMed
产品介绍background:
CD6 is a type I membrane protein expressed by thymocytes, mature T cells, a subset of B cells known as B1 cells, and some cells in the brain. CD6 is a member of the scavenger receptor cysteine rich (SRCR) family of proteins, which includes the leukocyte antigen CD5. The extracellular domain of CD6 is composed of three SRCR domains and has the same domain organization as CD5. The ligand for CD6 is CD166 also known as activated leukocyte cell adhesion molecule. Through its interaction with CD166 in the thymus, CD6 may have a role in T cell development.

Function:
Involved in cell adhesion. Binds to CD166.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

Post-translational modifications:
After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Contains intrachain disulfide bond(s).

Similarity:
Contains 3 SRCR domains.

Gene ID:
923

CD6,CD6抗体Database links:
Entrez Gene: 923 Human
Entrez Gene: 25752 Rat
Omim: 186720 Human
SwissProt: P30203 Human
Unigene: 744366 Human
Unigene: 57361 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD6是I型整合膜糖蛋白,属于SRCRSF（ scavenger receptor cysteine-rich superfamily）成员。CD6在外周血T细胞和髓质的胸腺细胞表面表达,也表达在皮质的胸腺细胞、B1细胞、某些NK细胞、脑细胞、T细胞或B细胞的慢性白血病细胞上。 CD6参与T细胞活化,调节T细胞功能和介导细胞-细胞间的粘附。CD6分子可与TCR/CD3形成复合体，参与免疫突触（immunological synapse，IS）的形成。
在自身性免疫性疾病发病机制中，T细胞增殖活化和迁移过程起着重要作用。基于CD6分子在淋巴细胞成熟、活化和增殖中的重要作用，阻断CD6分子的功能可为类风湿性关节炎、银屑病等自身免疫的治疗提供新的治疗手段和方法.