CD160,NK细胞受体BY55抗体

产品编号HZ-2526R
英文名称CD160
中文名称NK细胞受体BY55抗体
别 名By55; Natural killer cell receptor BY55; BY55; CD160 antigen [Precursor]; CD160 molecule; FLJ46513; Natural killer cell receptor BY55; NK1; NK28; BY55_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 细胞膜受体 自然杀伤细胞 t-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog,
CD160,NK细胞受体BY55抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量14.7kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD160
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD160,NK细胞受体BY55抗体PubMedPubMed
产品介绍background:
CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]

Function:
Receptor showing broad specificity for both classical and non-classical MHC class I molecules.

CD160,NK细胞受体BY55抗体Subunit:
Homomultimer; disulfide-linked.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Gene ID:
11126

Database links:
Entrez Gene: 11126 Human
Omim: 604463 Human
SwissProt: O95971 Human
Unigene: 488237 Human
Unigene: 740780 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.