CT-1,心肌营养素1抗体

产品编号HZ-2534R
英文名称CT-1
中文名称心肌营养素1抗体
别 名cardiotrophin-1; Cardiophin1; Cardiotrophin 1; Cardiotrophin I; CardiotrophinI; CT1; CTF 1; CTF1; CTF1_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CT-1,心肌营养素1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CT-1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CT-1,心肌营养素1抗体PubMedPubMed
产品介绍background:
Cardiotrophin-1 (CT-1), a cardiac hypertrophic factor, is a 21.5 kDa protein member of the IL-6 cytokine family. CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF kappa B DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to lower levels in lung, kidney, pancreas, thymus, testis and small intestine.

Function:
Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Subcellular Location:
Secreted.

CT-1,心肌营养素1抗体Tissue Specificity:
Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, colon or peripheral blood leukocytes.

Similarity:
Belongs to the IL-6 superfamily.

Gene ID:
1489

Database links:
Entrez Gene: 1489 Human
Entrez Gene: 29201 Rat
Omim: 600435 Human
SwissProt: Q16619 Human
SwissProt: Q63086 Rat
Unigene: 483811 Human
Unigene: 10253 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.