CACYBP,钙周期素结合蛋白抗体

产品编号HZ-3819R
英文名称CACYBP
中文名称钙周期素结合蛋白抗体
别 名CACYBP; Calcyclin binding protein; GIG 5; GIG5; Growth inhibiting gene 5; Growth inhibiting gene 5 protein; hCacyBP; PNAS 107; PNAS107; S100A6 binding protein; S100A6BP; SIP.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 转录调节因子 结合蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, .,
CACYBP,钙周期素结合蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量25kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human S100A6BP
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CACYBP,钙周期素结合蛋白抗体PubMedPubMed
产品介绍background:
SIAH Interacting Protein may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function:
May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Subunit:
Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.

Subcellular Location:
Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Post-translational modifications:
Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.

Similarity:
Contains 1 CS domain.
Contains 1 SGS domain.

CACYBP,钙周期素结合蛋白抗体Database links:
Entrez Gene: 27101 Human
Omim: 606186 Human
SwissProt: Q9HB71 Human
Unigene: 508524 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

钙周期素结合蛋白(Calcyclin-binding-protein, 又称siah-interaction-protein, CacyBP/SIP)与肿瘤的生长、转移相关，是一个26kDa以钙依赖的方式结合S100家族的蛋白,该蛋白的表达，与细胞周期的变化有关。