CRR9,顺氯氨铂耐药相关蛋白9抗体

产品编号HZ-6797R
英文名称CRR9
中文名称顺氯氨铂耐药相关蛋白9抗体
别 名Cisplatin resistance related protein 9; Cisplatin resistance related protein CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1 like protein; Cleft lip and palate transmembrane protein 1-like protein; CLP1L_HUMAN; CLPTM1 like; CLPTM1 like protein; CLPTM1-like protein; CLPTM1L; CRR9; CRR9p.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 细胞凋亡
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Horse,
CRR9,顺氯氨铂耐药相关蛋白9抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量62kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CLPTM1L/CRR9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CRR9,顺氯氨铂耐药相关蛋白9抗体PubMedPubMed
产品介绍background:
Clefts of the oral-facial region usually occur in early fetal development and can affect the lip, the soft palate and the hard palate. Cleft lip (with or without cleft palate) is a genetically complex birth defect that occurs in approximately one in every 750-1,000 live births. This is one of the most common birth defects and is multifactorial, with both genetic and environmental causes. Cleft lip- and palate-associated transmembrane protein 1 (CLPTM1) belongs to a family of cleft lip and palate transmembrane proteins. This family also contains cisplatin resistance-related protein (CRR9), which is involved in CDDP-induced apoptosis. CLPTM1L (cleft lip and palate transmembrane protein 1-like protein), also known as CRR9p (cisplatin resistance-related protein 9) is a 538 amino acid multi-pass membrane protein that belongs to the CLPTM1 family and, when overexpressed, enhances cisplatin-mediated apoptosis. CLPTM1L exists as two alternatively spliced isoforms encoded by a gene that maps to human chromosome 5p15.33.

Function:
Enhances cisplatin-mediated apoptosis, when overexpressed.

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).

Similarity:
Belongs to the CLPTM1 family

Gene ID:
81037

Database links:
Entrez Gene: 81037 Human
Omim: 612585 Human
SwissProt: Q96KA5 Human
Unigene: 444673 Human

CRR9,顺氯氨铂耐药相关蛋白9抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

顺氯氨铂属于细胞周期非特异性药物，具有细胞毒性，可抑制癌细胞的DNA复制过程，并损伤其细胞膜上结构，有较强的广谱抗癌作用。临床用于卵巢癌、前列腺癌、睾丸癌、肺癌、鼻咽癌、食道癌、恶性淋巴瘤、乳腺癌、头颈部鳞癌、甲状腺癌及成骨肉瘤等多种实体肿瘤均能显示疗效。