CPSF1,剪切及多聚腺苷酸化特异因子蛋白1抗体

产品编号HZ-14035R
英文名称CPSF1
中文名称剪切及多聚腺苷酸化特异因子蛋白1抗体
别 名Cleavage and polyadenylation specificity factor 160 kDa subunit; Cleavage and polyadenylation specificity factor subunit 1; CPSF 160 kDa subunit; CPSF160; HSU37012; P/cl.18.
说 明 书0.1ml 0.2ml
研究领域细胞生物 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
CPSF1,剪切及多聚腺苷酸化特异因子蛋白1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量161kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CPSF1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CPSF1,剪切及多聚腺苷酸化特异因子蛋白1抗体PubMedPubMed
产品介绍background:
Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Function:
CPSF1 (Cleavage and polyadenylation specificity factor subunit 1) is a component of the cleavage and polyadenylation specificity factor (CPSF) complex. It plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Subcellular Location:
Nucleus, nucleoplasm.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the CPSF1 family.

Gene ID:
29894

Database links:
Entrez Gene: 29894 Human
Entrez Gene: 94230 Mouse
Entrez Gene: 366952 Rat
Omim: 606027 Human
SwissProt: Q10570 Human
SwissProt: Q9EPU4 Mouse
SwissProt: B5DEL2 Rat
Unigene: 493202 Human

CPSF1,剪切及多聚腺苷酸化特异因子蛋白1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.