CTDSP1,羧基端小结构域磷酸酶1抗体

产品编号HZ-14098R
英文名称CTDSP1
中文名称羧基端小结构域磷酸酶1抗体
别 名Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1; CTDS1_HUMAN; CTDSP1; NIF3; NLI IF; NLI interacting factor 3; NLI-IF; NLI-interacting factor 3; NLIIF; Nuclear LIM interactor interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; Small CTD phosphatase 1.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
CTDSP1,羧基端小结构域磷酸酶1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CTDSP1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CTDSP1,羧基端小结构域磷酸酶1抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the small C-terminal domain phosphatase (SCP) family of nuclear phosphatases. These proteins play a role in transcriptional regulation through specific dephosphorylation of phosphoserine 5 within tandem heptapeptide repeats of the C-terminal domain of RNA polymerase II. The encoded protein plays a role in neuronal gene silencing in non-neuronal cells, and may also inhibit osteoblast differentiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Function:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Subunit:

Subcellular Location:
Nucleus. Colocalizes with RNA polymerase II.

Tissue Specificity:
Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.

Post-translational modifications:

CTDSP1,羧基端小结构域磷酸酶1抗体Similarity:
Contains 1 FCP1 homology domain.

Gene ID:
58190

Database links:
Entrez Gene: 58190 Human
Entrez Gene: 227292 Mouse
Omim: 605323 Human
SwissProt: Q9GZU7 Human
SwissProt: P58466 Mouse
Unigene: 444468 Human
Unigene: 165042 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.