CD79B,CD79B抗体

产品编号HZ-14644R
英文名称CD79B
中文名称CD79B抗体
别 名AGM6; B cell antigen receptor complex associated protein beta chain; B cell specific glycoprotein B29; B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; B29; B29/Ig-beta/CD79b; CD 79b; CD79b; CD79b antigen; CD79b molecule; CD79b molecule immunoglobulin associated beta; CD79b protein; CD79B_HUMAN; Ig beta; Ig-beta; IGB; Igbeta; Immunoglobulin associated B29; Immunoglobulin associated B29 protein; Immunoglobulin associated beta; Immunoglobulin associated protein; Immunoglobulin-associated B29 protein; MGC108607.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 淋巴细胞 b-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
CD79B,CD79B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量23kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CD79B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CD79B,CD79B抗体PubMedPubMed
产品介绍background:
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Function:
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

Subcellular Location:
Cell membrane. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts.

Tissue Specificity:
B-cells.

Post-translational modifications:
Phosphorylated on tyrosine upon B-cell activation.

DISEASE:
Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Similarity:
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Contains 1 ITAM domain.

Gene ID:
974

Database links:
Entrez Gene: 974 Human
Entrez Gene: 15985 Mouse
Entrez Gene: 171055 Rat
Omim: 147245 Human
SwissProt: P40259 Human
SwissProt: P15530 Mouse
Unigene: 89575 Human
Unigene: 2987 Mouse
Unigene: 62607 Rat

CD79B,CD79B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.