Phospho-Dab1 (Ser491),磷酸化Disabled 1抗体

产品编号HZ-3116R
英文名称Phospho-Dab1 (Ser491)
中文名称磷酸化Disabled 1抗体
别 名Dab1 (phospho Ser491); Dab1 (phospho S491); p-Dab1 (phospho Ser491); Dab 1; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari; Dab, reelin signal transducer, homolog 1 (Drosophila); Dab1; DAB1_HUMAN.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
Phospho-Dab1 (Ser491),磷酸化Disabled 1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human Dab1 around the phosphorylation site of Ser491
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospho-Dab1 (Ser491),磷酸化Disabled 1抗体PubMedPubMed
产品介绍background:
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Function:
Adapter molecule functioning in neural development. May regulate SIAH1 activity.

Subunit:
Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1. Interacts with LRP1.

Post-translational modifications:
Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons. Also phosphorylated on Ser-524 independently of reelin signaling.

Similarity:
Contains 1 PID domain.

Gene ID:
1600

Database links:
Entrez Gene: 374083 Chicken
Entrez Gene: 1600 Human
Entrez Gene: 13131 Mouse
Entrez Gene: 266729 Rat
Entrez Gene: 692351 Zebrafish
Omim: 603448 Human
SwissProt: O75553 Human
SwissProt: P97318 Mouse
SwissProt: Q8CJH2 Rat
Unigene: 477370 Human
Unigene: 289682 Mouse
Unigene: 206534 Rat

Phospho-Dab1 (Ser491),磷酸化Disabled 1抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.