EDEM3,EDEM3蛋白抗体

产品编号HZ-14502R
英文名称EDEM3
中文名称EDEM3蛋白抗体
别 名C1orf22; EDEM 3; edem3; EDEM3_HUMAN; ER degradation enhancer, mannosidase alpha like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation enhancing alpha mannosidase like 3; ER degradation-enhancing alpha-mannosidase-like 3.
说 明 书0.1ml 0.2ml
研究领域信号转导 转运蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
EDEM3,EDEM3蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量100kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human EDEM3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
EDEM3,EDEM3蛋白抗体PubMedPubMed
产品介绍background:
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008]

Function:
Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.

Subcellular Location:
Endoplasmic reticulum lumen.

Tissue Specificity:

Similarity:
Belongs to the glycosyl hydrolase 47 family.
Contains 1 PA (protease associated) domain.

Gene ID:
80267

EDEM3,EDEM3蛋白抗体Database links:
Entrez Gene: 80267 Human
Entrez Gene: 66967 Mouse
Entrez Gene: 289085 Rat
Omim: 610214 Human
SwissProt: Q9BZQ6 Human
SwissProt: Q2HXL6 Mouse
Unigene: 523811 Human
Unigene: 337691 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.