Slc22a5,溶质载体家族蛋白22成员5抗体上海沪震实业有限公司

性能参数

产品名称: Slc22a5,溶质载体家族蛋白22成员5抗体
英文名称: Anti-Slc22a5 antibody
抗体货号: HZ-8149R
产品规格: 0.1ml/0.2ml支
级    别: , , , , 分析纯, affinit
产品产地: 中国/美国
品牌商标: HZbscience
价    格: 询价
抗原: 多肽合成
抗原来源: Rabbit
抗体来源: 见说明书
适用物种: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep
见说明书conjugate:见说明书
Isotype:IgG
应用范围: WB,ELISA,IHC-P,IHC-F,IF
更新时间: 2016-10-19 16:10:00
详细资料:  实验方法技术资料
浏览人数:24
诚信指数:305点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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产品详细描述

Slc22a5,溶质载体家族蛋白22成员5抗体

产品编号HZ-8149R
英文名称Slc22a5
中文名称溶质载体家族蛋白22成员5抗体
别 名High-affinity sodium-dependent carnitine cotransporter; OCTN2; Organic cation/carnitine transporter 2; S22A5_HUMAN; Slc22a5; Solute carrier family 22 member 5.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 信号转导 通道蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
Slc22a5,溶质载体家族蛋白22成员5抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量58kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Slc22a5
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Slc22a5,溶质载体家族蛋白22成员5抗体PubMedPubMed
产品介绍background:
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. [provided by RefSeq, Jul 2008].

Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.

Subunit:
Interacts with PDZK1.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Slc22a5,溶质载体家族蛋白22成员5抗体Tissue Specificity:
Strongly expressed in kidney, skeletal muscle, heart and placenta. Highly expressed in intestinal cell types affected by Crohn disease, including epithelial cells. Expressed in CD68 macrophage and CD43 T-cells but not in CD20 B-cells.

DISEASE:
Defects in SLC22A5 are the cause of systemic primary carnitine deficiency (CDSP) [MIM:212140]. CDSP is an autosomal recessive disorder of fatty acid oxidation caused by defective carnitine transport. Present early in life with hypoketotic hypoglycemia and acute metabolic decompensation, or later in life with skeletal myopathy or cardiomyopathy.

Similarity:
Belongs to the major facilitator (TC 2.A.1)

Database links:
Entrez Gene: 6584 Human
Entrez Gene: 29726 Rat
Omim: 603377 Human
SwissProt: O76082 Human
SwissProt: O70594 Rat
Unigene: 443572 Human
Unigene: 8844 Rat

Slc22a5,溶质载体家族蛋白22成员5抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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