RNF19B,环指蛋白19B抗体

产品编号HZ-9246R
英文名称RNF19B
中文名称环指蛋白19B抗体
别 名E3 ubiquitin-protein ligase RNF19B; IBR domain containing 3; IBR domain-containing protein 3; IBRDC3; Natural killer lytic-associated molecule; NKLAM; RING finger protein 19B; RN19B_HUMAN; rnf19b.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学 t-淋巴细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
RNF19B,环指蛋白19B抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量78kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RNF19B
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RNF19B,环指蛋白19B抗体PubMedPubMed
产品介绍background:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

Subunit:
Interacts with UBE2L3, UBE2L6 and UCKL1.

Subcellular Location:
Cytoplasmic granule membrane.

RNF19B,环指蛋白19B抗体Tissue Specificity:
Expressed specifically in natural killer cells, activated macrophages and cytotoxic T-cells. Present in natural killer cells

Similarity:
Belongs to the RBR family. RNF19 subfamily.
Contains 1 IBR-type zinc finger.
Contains 2 RING-type zinc fingers.

Gene ID:
127544

Database links:
Entrez Gene: 127544 Human
Omim: 610872 Human
SwissProt: Q6ZMZ0 Human
Unigene: 591504 Human

RNF19B,环指蛋白19B抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.