别 名Cardiovascular heat shock protein; cvHsp; FLJ32733; Heat shock 27kda protein family member 7; Heat shock protein beta 7; Heat shock protein beta-7; Hsp25 2; HspB7; HSPB7_HUMAN; Hypothetical protein flj34956; RP11-5P18.6.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学 信号转导 细胞骨架
交叉反应 Human, Mouse, Rat, Chicken, Dog, Cow, Sheep,
HSPB7,热休克蛋白β7抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量19kDa
性 状Lyophilized or Liquid
免 疫 原KLH conjugated synthetic peptide derived from human HSPB7/cvHSP
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the small HSPs, the immunophilins and the HSP 110 family. HSPB7 (heat shock 27kDa protein family, member 7), also known as cvHSP (cardiovascular heat shock protein) or Heat shock protein beta-7, is a member of the small HSP (sHSP) family expressed in heart and skeletal muscle. Members of the sHSP family contain a conserved C-terminal ?crystallin domain and typically function in homo- or heteromeric complexes. The sHSPs bind to denatured proteins and are responsible for preventing the aggregation of these proteins. In response to muscle fiber transformation and in muscular dystrophy, the expression levels of HSPB7 are drastically increased, suggesting that HSPB7 may be a useful target in therapeutic strategies for preventing age-related muscle wasting.
Interacts with C-terminal domain of actin-binding protein 280.
Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
Belongs to the small heat shock protein (HSP20) family.
Entrez Gene: 27129 Human
Entrez Gene: 29818 Mouse
Entrez Gene: 50565 Rat
Omim: 610692 Human
SwissProt: Q9UBY9 Human
SwissProt: P35385 Mouse
SwissProt: Q5FW72 Mouse
SwissProt: Q9QUK5 Rat
Unigene: 502612 Human
Unigene: 46181 Mouse
Unigene: 21809 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.