phospho-RUNX3(Ser338),磷酸化Runx3抗体-抗体-抗体-生物在线
phospho-RUNX3(Ser338),磷酸化Runx3抗体

phospho-RUNX3(Ser338),磷酸化Runx3抗体

商家询价

产品名称: phospho-RUNX3(Ser338),磷酸化Runx3抗体

英文名称: Anti-phospho-RUNX3(Ser338) antibody

产品编号: HZ-4848R

产品价格: null

产品产地: 中国/美国

品牌商标: HZbscience

更新时间: 2023-08-17T10:24:20

使用范围: WB,ELISA,IHC-P,IHC-F,IF

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phospho-RUNX3(Ser338),磷酸化Runx3抗体

产品编号HZ-4848R
英文名称phospho-RUNX3(Ser338)
中文名称磷酸化Runx3抗体
别 名p-RUNX3(Ser338); RUNX 3; RUNX-3; Runt-related transcription factor 3; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; OncogeneAML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; Core-binding factor, alpha 3 subunit; CBF-alpha 3; Acute myeloid leukemia 2 protein; Oncogene AML-2; Polyomavirus enhancer-binding protein 2 alpha C subunit; PEBP2-alpha C; RUNX3_HUMAN; PEA2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 细胞生物 免疫学 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human,
phospho-RUNX3(Ser338),磷酸化Runx3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量44kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human RUNX3 around the phosphorylation site of Ser338
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-RUNX3(Ser338),磷酸化Runx3抗体PubMedPubMed
产品介绍background:
RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus.

Function:
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK.

Subcellular Location:
Nucleus. Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm.

Post-translational modifications:
Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.

Similarity:
Contains 1 Runt domain.

Gene ID:
864

phospho-RUNX3(Ser338),磷酸化Runx3抗体Database links:
Entrez Gene: 864 Human
Omim: 600210 Human
SwissProt: Q13761 Human
Unigene: 170019 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

RUNX3基因被认为是一种新发现的抑癌基因,对胃癌细胞的生长有明显的抑制作用在胃黏膜上皮细胞调控、对脊神经节的神经发育和T细胞分化中都发挥重要作用。 随着研究的不断深入,Runx3蛋白有望成为胃癌诊断的一个新型生物学标志物和基因治疗靶点。