ASP4/NAPSIN A,天冬氨酸蛋白酶ASP4抗体

产品编号HZ-4753R
英文名称ASP4/NAPSIN A
中文名称天冬氨酸蛋白酶ASP4抗体
别 名NAPSIN A; Asp 4; ASP4; Aspartyl protease 4; KAP; Kdap; Kidney derived aspartic protease like protein; NAP1; NAPA; Napsa; NAPSA_HUMAN; Napsin 1; napsin A aspartic peptidase; Napsin A precursor; Napsin-1; Napsin-A; Pronapsin A; SNAPA; TA01/TA02.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 激酶和磷酸酶 细胞类型标志物 肿瘤细胞生物标志物 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse,
ASP4/NAPSIN A,天冬氨酸蛋白酶ASP4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NAPSIN A/ASP4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ASP4/NAPSIN A,天冬氨酸蛋白酶ASP4抗体PubMedPubMed
产品介绍background:
Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. It is a 420-amino acid polypeptide consisting of a 24-residue signal peptide, a 40-amino acid propart, the mature enzyme of 336 amino acids, and a C-terminal extension of 18 residues. The mature Napsin A protein contains 3 predicted disulfide bonds, 3 potential N-linked oligosaccharide attachment sites, an RGD motif, a recognition motif for integrin binding, in the C terminus, immediately before a 4-amino acid insert that is unique to aspartic proteinases. Highest levels of Napsin A have been detected in adult lung (type II pneumocytes), fetal lung, and kidney tissues. Napsin A is also expressed at lower levels in adult spleen and at very low levels in peripheral blood leukocytes. Human napsin A shares 72.6% sequence identity with the mouse homolog.

Function:
May be involved in processing of pneumocyte surfactant precursors.

Subcellular Location:
Secreted (Potential).

Tissue Specificity:
Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Similarity:
Belongs to the peptidase A1 family.

Database links:
Entrez Gene: 9476 Human
Omim: 605631 Human
SwissProt: O96009 Human
Unigene: 512843 Human

ASP4/NAPSIN A,天冬氨酸蛋白酶ASP4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.