Gamma-taxilin,脂多糖相关反应蛋白5/γ-taxilin抗体

产品编号HZ-0631R
英文名称Gamma-taxilin
中文名称脂多糖相关反应蛋白5/γ-taxilin抗体
别 名chromosome X open reading frame 15; LSR5; CXorf15; Environmental lipopolysaccharide-responding gene protein; factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription; Factor inhibiting ATF4-mediated transcription antibody FIAT; Gamma-taxilin; Lipopolysaccharide-specific response protein 5; LSR5; TXLNG; TXLNG_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 干细胞 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse,
Gamma-taxilin,脂多糖相关反应蛋白5/γ-taxilin抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞核 细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Gamma-taxilin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Gamma-taxilin,脂多糖相关反应蛋白5/γ-taxilin抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Function:
May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression.

Subunit:
Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Forms a heterodimer with ATF4 in osteoblasts.

Subcellular Location:
Nucleus membrane. Cytoplasm, cytosol.

Tissue Specificity:
Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. Expressed in brain, placenta, lung, liver, kidney and pancreas.

Similarity:
Belongs to the taxilin family.

Database links:
Entrez Gene: 353170 Mouse
SwissProt: Q8BHN1 Mouse
Unigene: 270186 Mouse
Unigene: 371732 Mouse

Gamma-taxilin,脂多糖相关反应蛋白5/γ-taxilin抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.