Phospho-SRF (Ser77),磷酸化血清应答因子抗体

产品编号HZ-9602R
英文名称Phospho-SRF (Ser77)
中文名称磷酸化血清应答因子抗体
别 名Serum Response Factor SRF (phospho S77); SRF (phospho Ser77); P-SRF (Ser77); c fos serum response element binding factor; Serum Response Factor SRF; c fos serum response element binding transcription factor; ELK3; ERP; MCM 1; MCM-1; MCM1; OTTHUMP00000039820; SAP2; Serum response factor; SRF; SRF serum response factor c fos serum response element binding transcription factor; SRF_HUMAN.
说 明 书0.1ml
产品类型磷酸化抗体
研究领域肿瘤 干细胞 细胞凋亡 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow,
Phospho-SRF (Ser77),磷酸化血清应答因子抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated Synthesised phosphopeptide derived from human SRF around the phosphorylation site of Ser77
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Phospho-SRF (Ser77),磷酸化血清应答因子抗体PubMedPubMed
产品介绍background:
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].

Function:
SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation.

Subunit:
Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1. Forms a nuclear ternary complex with MKL1 and SCAI.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by PRKDC.

Similarity:
Contains 1 MADS-box domain.

Gene ID:
6722

Database links:
Entrez Gene: 6722 Human
Entrez Gene: 20807 Mouse
Entrez Gene: 501099 Rat
Omim: 600589 Human
SwissProt: P11831 Human
SwissProt: Q9JM73 Mouse
Unigene: 520140 Human
Unigene: 45044 Mouse

Phospho-SRF (Ser77),磷酸化血清应答因子抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

血清应答因子(SRF)是一种转录因子蛋白，可以结合启动子DNA序列中的血清应答元件(SRE)，调节一系列基因的表达，包括即刻早期基因的表达，如c-fos、fosB、junB、egr-1、egr-2，以及神经元基因nurr1、肌肉基因如肌动蛋白、肌球蛋白基因等.