NLGN4X,神经元X连锁蛋白/儿童自闭症相关蛋白抗体

产品编号HZ-11099R
英文名称NLGN4X
中文名称神经元X连锁蛋白/儿童自闭症相关蛋白抗体
别 名X-linked; HNLX; KIAA1260; Neuroligin X; Neuroligin-4; NLGN4; NLGN 4; NLGN4X; Neuroligin 4 X linked; Neuroligin 4; Neuroligin X; NLGN; NLGN-4; NLGN4X; NLGN4Y; NLGNX_HUMAN.
说 明 书0.1ml 0.2ml
研究领域发育生物学 神经生物学 细胞粘附分子 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Zebrafish, Chimpanzee,
NLGN4X,神经元X连锁蛋白/儿童自闭症相关蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量92kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human NLGN4X
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
NLGN4X,神经元X连锁蛋白/儿童自闭症相关蛋白抗体PubMedPubMed
产品介绍background:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

Function:
Putative neuronal cell surface protein involved in cell-cell-interactions.

Subunit:
Belongs to the type-B carboxylesterase/lipase family.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.

DISEASE:
Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism.

NLGN4X,神经元X连锁蛋白/儿童自闭症相关蛋白抗体Similarity:
Belongs to the type-B carboxylesterase/lipase family.

Gene ID:
57502

Database links:
Entrez Gene: 57502 Human
Omim: 300427 Human
SwissProt: Q8N0W4 Human
Unigene: 21107 Human

NLGN4X,神经元X连锁蛋白/儿童自闭症相关蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.