Amyloid β-Protein (1-42)

CompanySerial Number：HD130001

ProductName：Amyloid β-Protein (1-42)

Synonym：

CASNo.：107761-42-2

Sequence(three-letter)：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

Sequence(one-letter)： DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA-OH

ConstitutionalFormula：

MolecularFormula： C203H311N55O60S

MolecularWeight：4514.1

References： J.Kanget al., Nature, 325, 733 (1987)

D.Goldgaber et al., Science, 235, 877 (1987)

J.Murrell et al., Science, 254, 97 (1991)

C.J.Pike et al., Neuroscience, 63, 517 (1994)

M.Pitschke et al., Nat. Med., 4, 832 (1998)

G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)

W.B.Stine et al., J. Biol. Chem., 278, 11612 (2003)

D.A.Butterfield and D.Boyd-Kimball, Biochim. Biophys. Acta, 1703, 149 (2005)

S.Gandy, J. Clin. Invest., 115, 1121 (2007)

D.M.Walsh and D.J.Selkoe, J. Neurochem., 101, 1172 (2007)

A.Jan et al., Nat. Protoc., 5, 1186 (2010)

Illustration：This42-residue fragment of amyloid β-protein has been found to be a majorconstituent of the senile plaques formed in the brains of patients withAlzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxicoligomers at physiological pH. The peptide has been used to detect amyloidβ-protein multimers in the cerebrospinal fluid of Alzheimer's disease patientsthrough fluorescence correlation spectroscopy. For detailed descriptions of thepreparation of Aβ 1-42 monomers and protofibrils please see the paper of Jan,Hartley, and Lashuel.

ConditionOf Storage: -20± 5 °C