Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)武汉纽斯特生物技术有限公司

性能参数

产品名称: Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)
英文名称: Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)
抗体货号: 21001
产品规格: 100ul
级    别: 生化级,
产品产地: 美国
品牌商标: NewEastbio
价    格: 1600元
抗原: A peptide from the extracellular loop 1 region of human Orai1
抗原来源: 
抗体来源: 兔
适用物种: 脊椎动物
Isotype: IgG
应用范围: ELISA, WB, IHC
更新时间: 2018/8/6 15:08:00
详细资料:  点击查看
浏览人数:823
诚信指数:78点
了解更多:进入公司展台
使用范围:仅限科研使用,不能应用于临床
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供应商联系卡

武汉纽斯特生物技术有限公司
地址:
武汉市东湖新技术开发区光谷生物城B3-3栋2-3楼
邮编:
430074
电话:
027-87561033 手机 18627017297
传真:
027-87561022
联系人:
黄先生
所在区域:
湖北·武汉
邮件:
公司展台:

产品详细描述

Orai1-L1 [21001]
[100 µL]
 

Catalog Number:  21001
Gene Symbol:  Orai1
Description:   Anti-Orai1 Rabbit Polyclonal Antibody (Orai1-L1)
Background:   Store-operated calcium channels (SOCs) play essential functions in various physiological processes. Orai1 (also named CRACM1) is a critical molecular component of SOCs. Orai1 protein is a ~35 kDa plasma membrane protein with 4 transmembrane domains. Human patients with a severe combinaed immunodeficiency (SCID) syndrome possess point mutations in Orai1 gene.
Immunogen:   A peptide from the extracellular loop 1 region of human Orai1
Applications:   ELISA, WB, IHC
Recommended Dilutions:   
ELISA:      1:1000-1:5000,
WB:          1:1000-1:2000,
IHC:          1:100-1:200
Concentration:   
Host:   Rabbit
Format:   Liquid
Clonality:   Polyclonal
Isotype:   IgG
Purity:   Immunogen affinity purified
Storage buffer:
Preservative:  0.01% sodium azide
Constituents:   50mM NaHCO3-Glycine, 0.15M NaCl, pH7.4
Species Reactivity:  Orai1-L1 antibody recognizes Orai1 from human and mouse. It may also recognize Orai2 and Orai3.
Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
 
Western blot:  
Western blot analysis of Orai1 protein. Human Orai1 plasmid DNA was transiently transfected into HEK-293 cells. Whole-cell lysate was used for western blot in the absence (lane 1) or presence (lane 2) of antigen peptide.
Immunohistochemistry   
Immunohistochemistry of endogenous Orai1 in NIH3T3 cells showing the plasma membrane staining.
Publications:
1.  Generation and Characterization of Fully Human Monoclonal Antibodies Against Human Orai1 for Autoimmune Disease
    J Pharmacol Exp Ther. 2013 May;345(2):225-38
2.  Influence of Orai1 intervention on mouse airway epithelium reactions in vivo and in vitro
    Ann Allergy Asthma Immunol. 2012 Feb;108(2):103-12
3.  2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis
    Am J Otolaryngol. 2011 Jul-Aug;32(4):318-28
4.  Up-regulation of Orai1 in murine allergic rhinitis
    Histochem Cell Biol. 2010 Jul;134(1):93-102
5.  Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
    Cancer Cell. 2009 Feb 3;15(2):124-34
6.  Amelioration of Muc5b mucin hypersecretion is enhanced by IL-33 after 2-APB administration in a murine model of allergic rhinitis
    Biotech Histochem. 2014 May;89(4):273-86

 

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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