Rabbit Anti-phospho-FXYD1 (Ser88) antibody
|别 名||FXYD1 (phospho S88); FXYD1 (phospho Ser88); p-FXYD1 (phospho S88); FXYD domain containing ion transport regulator 1; Phospholemman; PLM; fxyd1; PLM_HUMAN; FXYD domain-containing ion transport regulator 1.|
|研究领域||肿瘤 免疫学 神经生物学 通道蛋白 新陈代谢|
|交叉反应||Human, Rat, Dog, Pig, Cow, Sheep,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||10kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human FXYD1 around the phosphorylation site of Ser88:RL(p-S)TR|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
PLM (FXYD1)is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. PLM may be phosphorylated by several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity.
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
Membrane; single-pass type I membrane protein
Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK.
Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.
Belongs to the FXYD family.
Entrez Gene: 476487 Dog
Entrez Gene: 5348 Human
Entrez Gene: 56188 Mouse
Entrez Gene: 58971 Rat
Omim: 602359 Human
SwissProt: P56513 Dog
SwissProt: O00168 Human
SwissProt: Q9Z239 Mouse
SwissProt: O08589 Rat
Unigene: 442498 Human
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.