磷酸化细胞核分离基因C蛋白抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化细胞核分离基因C蛋白抗体
英文名称: phospho-NUDC(Ser326)
抗体货号: hz-7842R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
更新时间: 2018/4/13 16:33:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-NUDC(Ser326) antibody

 

产品编号 hz-7842R
英文名称 phospho-NUDC(Ser326)
中文名称 ***酸化细胞核分离基因C蛋白抗体
别    名 NUDC (phospho S326); NUDC (phospho Ser326); p-NUDC(S326); p-NUDC(Ser326); HNUDC; MNUDC; MNUDC protein; NPD011; Nuclear distribution gene C (A.nidulans) homolog; Nuclear distribution gene C homolog; Nuclear distribution gene C homolog (A. nidulans); Nuclear distribution protein C homolog; Nuclear migration protein nudC; nudC; NUDC_HUMAN; OTTHUMP00000004405; SIG 92; SIG92.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  神经生物学  细胞周期蛋白  细胞分化  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 38kDa
细胞定位 细胞核 细胞浆 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human NUDC around the phosphorylation site of Ser326:DF(p-S)KA 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012].

Function:
Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

Subunit:
Binds PLK1. Binds PAFAH1B1 (By similarity). Part of a complex containing PLK1, NUDC, dynein and dynactin.

Subcellular Location:
Cytoplasm, cytoskeleton. Nucleus. Note=In a filamentous pattern adjacent to the nucleus of migrating cerebellar granule cells. Colocalizes with tubulin and dynein and with the microtubule organizing center. Distributed throughout the cytoplasm of non-migrating cells. A small proportion is nuclear, in a punctate pattern.

Tissue Specificity:
Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.

Post-translational modifications:
Reversibly phosphorylated on serine residues during the M phase of the cell cycle. Phosphorylation on Ser-274 and Ser-326 is necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Phosphorylated by PLK and other kinases.

Similarity:
Belongs to the nudC family. 
Contains 1 CS domain.

Gene ID:
10726

Database links:

Entrez Gene: 10726 Human

Entrez Gene: 18221 Mouse

Entrez Gene: 29648 Rat

Omim: 610325 Human

SwissProt: Q9Y266 Human

SwissProt: O35685 Mouse

SwissProt: Q63525 Rat

Unigene: 263812 Human

Unigene: 69 Mouse

Unigene: 10413 Rat

NCBI Reference Sequence: NP_006591.1
UniProtKB/Swiss-Prot: Q9Y266.1



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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