磷酸化细胞内流钾通道蛋白Kir5.1抗体上海沪震实业有限公司

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产品名称: 磷酸化细胞内流钾通道蛋白Kir5.1抗体
英文名称: phospho-KIR5.1(Ser416)
抗体货号: hz-12180R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/9/17 11:35:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-phospho-KIR5.1(Ser416) antibody

 

产品编号 hz-12180R
英文名称 phospho-KIR5.1(Ser416)
中文名称 ***酸化细胞内流钾通道蛋白Kir5.1抗体
别    名 KIR5.1 (phospho S416); p-KIR5.1 (phospho S416); 6430410F18Rik; AI132396; BIR9; Inward rectifier K channel Kir5.1; Inward rectifier K(+) channel Kir5.1; Inward rectifier potassium channel 16; IRK16; IRKG; KCNJ16; MGC33717; Potassium channel inwardly rectifying subfamily J member 16; Potassium inwardly rectifying channel subfamily J member 16; RP23-218O16.1; IRK16_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  神经生物学  信号转导  通道蛋白  细胞膜受体  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human KIR5.1 around the phosphorylation site of Ser416:VE(p-S)QM 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The KIR family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. Kir4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. Kir4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human Kir4.1 maps to chromosome 1. Kir4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human Kir4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and Kir4.2 may play a role in the pathogenesis of Down’s syndrome. Kir 5.1 forms functional channels only by coexpression with either Kir4.1 or Kir4.2 in the kidney and pancreas. The gene encoding human Kir5.1 maps to chromosome 17.

Function:
KIR5.1 is one of 20 members of the inwardly rectifying potassium (Kir) channel family. Due to its expression in kidney, pancreas and thyroid gland, it has been suggested that human KIR5.1 may be involved in the regulation of fluid and pH balance, thus making it a potential therapeutic target for hypertension, renal failure, or pancreatic disease. 

Subunit:
Seems to form heterodimer with Kir4.1/KCNJ10 or Kir2.1/KCNJ2. 

Subcellular Location:
Membrane; Multi pass membrane protein. 

Tissue Specificity:
Highly expressed in kidney, pancreas and thyroid gland. 

Similarity:
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ16 subfamily. 

Gene ID:
3773

Database links:

Entrez Gene: 3773 Human

Entrez Gene: 16517 Mouse

Entrez Gene: 29719 Rat

Omim: 605722 Human

SwissProt: Q9NPI9 Human

SwissProt: Q9Z307 Mouse

SwissProt: P52191 Rat

Unigene: 463985 Human

Unigene: 1989 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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