Rabbit Anti-phospho-Acetyl Coenzyme A Carboxylase beta (Ser220) antibody
|英文名称||phospho-Acetyl Coenzyme A Carboxylase beta (Ser220)|
|别 名||Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase beta (phospho Ser221); p-Acetyl Coenzyme A Carboxylase beta (phospho S221); Acetyl Coenzyme A Carboxylase; ACAS2; AceCS; Acetate CoA ligase; Acetyl CoA synthetase; Acetyl coenzyme A synthetase cytoplasmic; Acetyl-CoA synthetase; ACS; ACSS2; Acyl activating enzyme; Acyl CoA synthetase short chain family member 2; EC 18.104.22.168; MYH7B; ACACB; ACC beta; ACC2; ACCB; Acetyl CoA carboxylase 2; Acetyl CoA carboxylase beta; Biotin carboxylase; COA2; HFA1; ACACB_HUMAN.|
|研究领域||肿瘤 心血管 细胞生物 转录调节因子|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||265kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from human Acetyl Coenzyme A Carboxylase beta around the phosphorylation site of Ser220:RP(p-S)M|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Endomembrane system. Note=May associate with membranes.
Predominantly expressed in the heart, skeletal muscles and liver.
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain.
Entrez Gene: 31 Human
Entrez Gene: 32 Human
Entrez Gene: 100705 Mouse
Entrez Gene: 107476 Mouse
Entrez Gene: 116719 Rat
Entrez Gene: 60581 Rat
Omim: 200350 Human
Omim: 601557 Human
SwissProt: O00763 Human
SwissProt: Q13085 Human
SwissProt: Q5SWU9 Mouse
SwissProt: O70151 Rat
SwissProt: P11497 Rat
Unigene: 160556 Human
Unigene: 234898 Human
Unigene: 44372 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications