磷酸化腺苷三磷酸结合盒转运体A1抗体上海沪震实业有限公司

性能参数

产品名称: 磷酸化腺苷三磷酸结合盒转运体A1抗体
英文名称: phospho-ABCA1 (Ser2054)
抗体货号: hz-12956R
产品规格: 100ul
级    别: , , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 1580元
抗原: IgG
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 见说明书
应用范围: ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500
更新时间: 2018/6/28 14:45:00
详细资料:  实验方法技术资料
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使用范围:仅限科研使用,不能应用于临床
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产品详细描述

 Rabbit Anti-phospho-ABCA1 (Ser2054) antibody

 

产品编号 hz-12956R
英文名称 phospho-ABCA1 (Ser2054)
中文名称 ***酸化腺苷三***酸结合盒转运体A1抗体
别    名 ABCA1 (phospho S2054); p-ABCA1 (phospho S2054); ATP binding cassette transporter A1; ABC 1; ABC Transporter 1; ABC1; ABCA 1; ABCA1; ATP binding Cassette 1; ATP binding cassette sub family A ABC1 member 1; ATP binding cassette sub family A member 1; ATP binding cassette sub-family A member 1; ATP binding Cassette Transporter 1; ATP-binding Cassette 1; ATP-binding Cassette Transporter 1; CERP; Cholesterol Efflux Regulatory Protein; FLJ14958; HDLDT1; Membrane bound; MGC164864; MGC165011; TD; TGD; ABCA1_HUMAN.  
   
产品类型 ***酸化抗体 
研究领域 肿瘤  细胞生物  信号转导  新陈代谢  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, 
产品应用 ELISA=1:500-1000 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 254kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human ABCA1 around the phosphorylation site of Ser2054:KL(p-S)TA 
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Function:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.

Subunit:
Interacts with MEGF10. 

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed, but most abundant in macrophages.

Post-translational modifications:
Phosphorylation on Ser-2054 regulates phospholipid efflux. Palmitoylation by DHHC8 is essential for membrane localization.

DISEASE:
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier disease (TGD). HDLD1 is a recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
Defects in ABCA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). HDLD2 is inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.

Similarity:
Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains.

Gene ID:
19

Database links:

Entrez Gene: 19 Human

Entrez Gene: 11303 Mouse

Entrez Gene: 313210 Rat

Omim: 600046 Human

SwissProt: O95477 Human

SwissProt: P41233 Mouse

Unigene: 429294 Human

Unigene: 277376 Mouse

Unigene: 148916 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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