Rabbit Anti-Phospho-5-Lipoxygenase(Ser523) antibody
|别 名||5-Lipoxygenase(Phospho Ser523); 5-Lipoxygenase(Phospho S523); p-5-Lipoxygenase(Ser523); 5-lipoxygenase; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonic acid 5 lipoxygenase; Leukotriene A4 synthase; LOG 5; LOG5; MGC163204; LOX5_HUMAN.|
|研究领域||肿瘤 免疫学 信号转导 转录调节因子 激酶和***酸酶 合成与降解|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||78kDakDa|
|细胞定位||细胞核 细胞浆 细胞膜 细胞外基质|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthesised phosphopeptide derived from rat 5-Lipoxygenase around the phosphorylation site of Ser523:461-560/673|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes.
Interacts with ALOX5AP and LTC4S.
Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein.
Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus.
Belongs to the lipoxygenase family.
Contains 1 lipoxygenase domain.
Contains 1 PLAT domain.
Entrez Gene: 240 Human
Entrez Gene: 11689 Mouse
Entrez Gene: 25290 Rat
Omim: 152390 Human
SwissProt: P09917 Human
SwissProt: P48999 Mouse
SwissProt: P12527 Rat
Unigene: 89499 Human
Unigene: 41072 Mouse
Unigene: 9662 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications