Rabbit Anti-phospho-Ephrin B1 (Tyr317) antibody
|英文名称||phospho-Ephrin B1 (Tyr317)|
|别 名||phospho-Ephrin B1 (phospho Y317); Ephrin B (phospho Y317); p-Ephrin B (phospho Y317); phospho-Ephrin B1 (Tyr317); phospho-Ephrin B2(Tyr316); CEK5 ligand; EFNB1; ELK L; EphrinB; Ephrin-B; ELK ligand; ELKL; EPH related receptor tyrosine kinase ligand 2; Ephrin B Precursor; Ephrin B1; Ephrin B2; LERK 2; LERK2; EFNB1_HUMAN; EFNB2_HUMAN.|
|研究领域||肿瘤 细胞生物 神经生物学 生长因子和激|
|交叉反应||Human, Mouse, Rat, Cow, Horse,|
|产品应用||WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||34kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised phosphopeptide derived from human Ephrin B1 around the phosphorylation site of Tyr317:PH(p-Y)EK|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.
Interacts with GRIP1 and GRIP2. Binds to Nipah virus G protein.
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
Membrane; single pass type I membrane protein.
Belongs to the ephrin family.
Contains 1 ephrin RBD (ephrin receptor-binding) domain.
Entrez Gene: 1947 Human
Entrez Gene: 1948 Human
Entrez Gene: 13641 Mouse
Entrez Gene: 13642 Mouse
Entrez Gene: 25186 Rat
Omim: 300035 Human
Omim: 600527 Human
SwissProt: P52799 Human
SwissProt: P98172 Human
SwissProt: P52795 Mouse
SwissProt: P52800 Mouse
SwissProt: P52796 Rat
SwissProt: Q6P7B6 Rat
Unigene: 144700 Human
Unigene: 149239 Human
Unigene: 44398 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications