Rabbit Anti-Histone H1 (acetyl K25) antibody
|英文名称||Histone H1 (acetyl K25)|
|别 名||H10; H10_HUMAN; h1f0; H1FV; Histone H1''; Histone H1(0); Histone H10; Histone H5; MGC5241; N-terminally processed.|
|交叉反应||Human, Mouse, Rat, Pig, Cow, Sheep,|
|产品应用||ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||21kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated Synthesised acetylpeptide derived from human Histone H1 around the acetylation site of K25:|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.
Nucleus. Chromosome. The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Phosphorylated on Ser-17 in RNA edited version.
Belongs to the histone H1/H5 family. Contains 1 H15 (linker histone H1/H5 globular) domain.
Entrez Gene: 3005 Human
Entrez Gene: 14958 Mouse
Entrez Gene: 24437 Rat
Omim: 142708 Human
SwissProt: P07305 Human
SwissProt: P10922 Mouse
SwissProt: P43278 Rat
Unigene: 745024 Human
Unigene: 24350 Mouse
Unigene: 3129 Rat
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications