FITC标记的N-乙酰转移酶8B抗体
产品名称： FITC标记的N-乙酰转移酶8B抗体
英文名称： Anti-NAT8B/FITC
产品编号： HZ-11592R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-NAT8B/FITC Conjugated antibody
FITC标记的N-乙酰转移酶8B抗体
| 产品编号 | bs-11592R-FITC |
| 英文名称 | Anti-NAT8B/FITC |
| 中文名称 | FITC标记的N-乙酰转移酶8B抗体 |
| 别 名 | Camello like protein 2; Camello-like protein 2; CML2; Hcml2; N acetyltransferase 8B; NAT8B; NAT8B_HUMAN; NAT8BP; Probable N acetyltransferase 8B; Probable N-acetyltransferase 8B. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 发育生物学 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NAT8B |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: Acetyltransferases and deacetylases are protein groups most often associated with oncogenesis and cell cycle regulation. NAT-8B (N-acetyltransferase 8B), also known as CML2 (camello-like protein 2), is a 227 amino acid single-pass membrane protein that is implicated in gastrulation regulation. A member of the camello family, NAT-8B contains one N-acetyltransferase domain and is encoded by a gene that maps to human chromosome 2p13.2. The NAT-8B gene is susceptible to a nonsense mutation at Serine 16, which leads to a stop codon and subsequently, a non-functional protein that is truncated in length. Similarly, a nonsense mutation at Glutamine 168 is thought to lead to a non-functional protein, as it causes the N-acetyltransferase to become disrupted. Human chromosome 2 consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: May play a role in regulation of gastrulation. Subcellular Location: Membrane; Single-pass membrane protein Similarity: Belongs to the camello family. Contains 1 N-acetyltransferase domain. Database links: Entrez Gene: 51471 Human NCBI: NP_057431 Human Omim: 608190 Human SwissProt: Q9UHF3 Human Unigene: 728429 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
乙酰转移酶和去乙酰化酶是最常与肿瘤发生和细胞周期调控相关的蛋白质组。NAT-8B（N-乙酰基转移酶8B），也称CML2（CAMELO样蛋白2），是一种与原肠调节相关的227氨基酸单程膜蛋白。CAMELO家族成员NAT-8B包含一个N-乙酰转移酶结构域，并由一个映射到人类染色体2p132的基因编码。NAT-8B基因易受丝氨酸16的无义突变的影响，从而导致终止密码子，随后是截短长度的非功能蛋白。类似地，谷氨酰胺168的无义突变被认为导致非功能性蛋白质，因为它导致N-乙酰基转移酶被破坏。人类2号染色体由2亿3700万个碱基组成，编码超过1400个基因，约占人类基因组的8%。许多遗传性疾病与2号染色体上的基因有关，包括疣状水肿、谷甾醇血症和阿尔斯特罗氏综合征。