FITC标记的丝氨酸/苏氨酸蛋白激酶PCTK2抗体
产品名称： FITC标记的丝氨酸/苏氨酸蛋白激酶PCTK2抗体
英文名称： Anti-PCTAIRE2/FITC
产品编号： HZ-11574R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCTAIRE2/FITC Conjugated antibody
FITC标记的丝氨酸/苏氨酸蛋白激酶PCTK2抗体
| 产品编号 | bs-11574R-FITC |
| 英文名称 | Anti-PCTAIRE2/FITC |
| 中文名称 | FITC标记的丝氨酸/苏氨酸蛋白激酶PCTK2抗体 |
| 别 名 | PCTAIRE-2; PCTAIRE-motif protein kinase 2; PCTK2; Protein kinase cdc2-related PCTAIRE-2; Serine/threonine-protein kinase PCTAIRE-2; 6430598J10Rik; EC 2.7.1.37; MGC25109; CDK17_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, Sheep, shp |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 60kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCTAIRE2 (301-400aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with cyclins to phosphorylate key substrates involved in cell cycle progression. Another family of proteins, Cdk inhibitors, also play a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Members of the Cdk family include Cdk2–Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. PCTAIRE-1, PCTAIRE-2 and PCTAIRE-3 comprise a subfamily of cdc2-related serine/threonine kinases. PCTAIRE-1, which is expressed primarily in mammalian brain, interacts with a variety of proteins and is thought to be part of a multiple signal transduction cascade. PCTAIRE-2, also expressed in brain, may be important in terminally differentiated neurons. Function: PCTAIREs are members of a subfamily of Cdc2-related kinases that are preferentially expressed in post-mitotic cells. PCTAIRE 2 is specifically expressed in the brain. Within the brain, PCTAIRE 2 is concentrated in the neuronal layers of the hippocampus and olfactory bulb, which mostly consist of post-mitotic neurons. In an immunocytochemical study, immunoreactivity for PCTAIRE 2 was detected in the cell bodies and extended neurites of neurons, but not in astrocytes. The PCTAIRE 2 protein is recovered in the particulate fraction and is resistant to solubilization with non-ionic detergent, suggesting that PCTAIRE 2 might be present as a component of a large protein complex. An immunoprecipitation assay revealed that the PCTAIRE 2 is associated with Ser/Thr-phosphorylating activity for histone H1, and that its activity depends on association with a regulatory partner that can be released under high-salt conditions. These findings suggest that PCTAIRE 2 is a Ser/Thr kinase that might play a unique role in terminally differentiated neurons. Subunit: Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7 Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Database links: UniProtKB/Swiss-Prot: Q00537.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
细胞周期的进展部分由细胞周期蛋白家族和细胞周期蛋白依赖性激酶（CDKs）控制。CDK蛋白与细胞周期蛋白协同作用，以磷酸化参与细胞周期进程的关键底物。另一个家族的蛋白质，CDK抑制剂，也发挥了作用，通过调节细胞周期与细胞周期蛋白CDK复合物和调节其活性。Cdk家族成员包括CDK2-CDK8、PcTayRe-1—3、PITALRE和PITSRRE。PcTayRe-1、PCTaEr-2和PcTayRe-3包括CDC2相关丝氨酸/苏氨酸激酶亚家族。PcTayRe-1主要在哺乳动物脑中表达，与多种蛋白质相互作用，被认为是多信号转导级联的一部分。PcTayRe-2也在脑中表达，在终末分化神经元中可能是重要的。