FITC标记的转录因子Gli2抗体上海沪震实业有限公司

性能参数

产品名称: FITC标记的转录因子Gli2抗体
英文名称: Anti-Gli2/FITC
抗体货号: HZ-11564R-FITC
产品规格: 100ul
级    别: 分析纯, , 分析纯,
产品产地: 中国/上海
品牌商标: HZbscience
价    格: 2980元
抗原: Rabbit
抗原来源: Rabbit
抗体来源: Rabbit
适用物种: 
FITCconjugate:FITC
应用范围: ICC=1:50-200 IF=1:50-200
更新时间: 2018/6/13 16:15:00
详细资料:  实验方法技术资料
浏览人数:4
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使用范围:仅限科研使用,不能应用于临床
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上海沪震实业有限公司
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产品详细描述

 Rabbit Anti-Gli2/FITC Conjugated antibody

FITC标记的转录因子Gli2抗体

 

产品编号 bs-11564R-FITC
英文名称 Anti-Gli2/FITC
中文名称 FITC标记的转录因子Gli2抗体
别    名 Gli 2; Gli-2; GLI family zinc finger 2; GLI kruppel family member 2; GLI Kruppel family member GLI2; GLI2; GLI2_HUMAN; Oncogene GLI2; Tax helper protein 2; Tax helper protein; Tax responsive element 2 holding protein; Tax responsive element 25 bp sequence binding protein; THP 2; THP; THP2; Zinc finger protein GLI2.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  神经生物学  信号转导  干细胞  转录调节因子  锌指蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 168kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Gli2
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
It has long been known that the overexpression of either Wnt-1 or the GLI proteins results in cancer; however, the molecular basis for this transformation was poorly understood. The Wnt-1 and GLI proteins have now been placed in a signaling cascade downstream of the mammalian homologs of the Drosophila hedgehog and patched proteins. The Drosophila segment polarity gene hedgehog (hh) encodes a secreted protein that appears to function in embryonic and imaginal disc patterning. The ptc gene, also identified as a Drosophila segment polarity gene, encodes the transmembrane protein patched, the expression of which is precisely regulated during embryonic development. Hedgehog has been shown to enhance the expression of the Wnt family of proteins through a signaling cascade involving the GLI transcription factors, while patched functions as a repressor opposing the effects of hedgehog. Mutations in the ptc gene, which result in unregulated hedgehog signaling, have been correlated with the most common type of cancer, basal cell carcinoma, which affects 750,000 individuals annually in the United States alone.

Function:
FunctionActs as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. 

Subunit:
Interaction with ZIC

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated in vitro by ULK3.

DISEASE:
Defects in GLI2 are the cause of holoprosencephaly type 9 (HPE9) [MIM:610829]; also called pituitary anomalies with holoprosencephaly-like features. The primary features of this disease include defective anterior pituitary formation and pan-hypopituitarism, with or without overt forebrain cleavage abnormalities, and holoprosencephaly-like midfacial hypoplasia. Holoprosencephaly is the most common structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.

Similarity:
Belongs to the GLI C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.

Database links:

UniProtKB/Swiss-Prot: P10070.4

Entrez Gene: 2736 Human

Entrez Gene: 14633 Mouse

Omim: 165230 Human

SwissProt: P10070 Human

SwissProt: Q0VGT2 Mouse

SwissProt: Q8K0K3 Mouse

Unigene: 111867 Human

Unigene: 273292 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

长期以来,无论是Wnt-1或GLI蛋白的过度表达都会导致癌症,然而,这种转化的分子基础却知之甚少。Wnt-1和GLI蛋白现在已被放置在果蝇刺猬和补丁蛋白的哺乳动物同源物下游的信号级联。果蝇片段极性基因Hedgehog(HH)编码分泌蛋白,其在胚胎和想象的椎间盘构型中发挥作用。PTC基因,也被鉴定为果蝇片段极性基因,编码跨膜蛋白补丁,其表达在胚胎发育过程中被精确调节。刺猬已被证明通过WLNT蛋白家族的表达通过涉及GLI转录因子的信号级联来增强,而补丁功能作为抑制Hedgehog效应的阻遏物。PTC基因的突变,导致未调节的刺猬信号,已与最常见的类型的癌症,基底细胞癌,每年仅影响750000个人在美国。

生物在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。

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