Rabbit Anti-FOXB1/FITC Conjugated antibody
|别 名||FKH 5; FKH5; Forkhead box B1; Forkhead box protein B1; FOX B1; FOXB 1; HFKH 5; Transcription factor FKH 5; Transcription factor FKH5; FOXB1_HUMAN.|
|规格价格||100ul/2980元 购买 大包装/询价|
|说 明 书||100ul|
|研究领域||信号转导 转录调节因子 表观遗传学|
|交叉反应||Human, Mouse, Rat, Chicken, Cow, Sheep,|
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
|分 子 量||35kDa|
|性 状||Lyophilized or Liquid|
|免 疫 原||KLH conjugated synthetic peptide derived from human FOXB1 (1-100aa)|
|纯化方法||affinity purified by Protein A|
|储 存 液||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.|
|保存条件||Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.|
The Forkhead-box (FOX) genes comprise a superfamily of at least 43 members that encode proteins which are involved in transcriptional regulation and may be associated with the pathogenesis of various cancers. FOXB1 (forkhead box B1), also known as FKH5 or HFKH-5, and FOXB2 (forkhead box B2) are members of the FOX family and each contain one forkhead DNA-binding domain. Both FOXB1 and FOXB2 localize to the nucleus where they are thought to function as transcription factors that can bind to DNA via their forkhead domains. In mice, defects in the gene encoding FOXB1 are associated with retarded development of the central nervous system (CNS), suggesting that FOXB1 may play a role in CNS organization and function.
FOXB1 and FOXB2 are winged helix/forkhead transcription factors. FOXB1 is specifically expressed in the developing central nervous system (CNS). Early embryonic FOXB1 expression is restricted to the mammiliary body region of the caudal hypothalamus, midbrain, hindbrain and spinal cord. FOXB1 may play a role in postnatal growth, lactation and CNS development.
Contains 1 fork-head DNA-binding domain.
Entrez Gene: 27023 Human
Entrez Gene: 64290 Mouse
Entrez Gene: 367106 Rat
SwissProt: Q99853 Human
SwissProt: Q99MX1 Mouse
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application
的叉头框（福克斯）基因超家族包括进入该成员是在43个最小编码蛋白参与调节细胞transcriptional和可能是相关的各种cancers）与病程。foxb1（叉头框B1），也被称为fkh5或hfkh - 5，和foxb2（叉头框（B2）的是福克斯家族的成员和每个包含一个DNA结合域的转录。这两个foxb1和foxb2定位到核函数的思想，在他们的转录因子可以绑定到的DNA通过其转录域。缺陷小鼠中的基因编码，是相关联的foxb1研究开发中央神经系统（CNS），提示可能发挥的作用，foxb1在中枢神经系统中的组织和功能。